Human Niemann Pick Type C (Male) iPSCs

SKU: CR1012-500 Category:

Human Niemann Pick Type C (Male) iPSCs

$1,050.00

Cryopreserved vial of induced pluripotent stem cells from a single male donor with Niemann-Pick disease type C (~500,000 cells)

Quantity

Typically ships in:
1 - 2 business days

SKU: CR1012-500 Category:

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Product Overview

The cell line was derived from an 11-year-old man with NPC1 mutation. The donor was clinically affected with splenomegaly and supranuclear palsy and subsequently received intravenous and intrathecal cyclodextrin. Other subsequent features included uncoordinated movements and seizures.

Prior cell-based studies to understand NPC cellular pathophysiology and screen for therapeutic agents have primarily used patient fibroblasts, which do not allow for modeling the neurodegenerative aspect of NPC disease. These cells can be used for high-throughput drug/chemical screening to identify potential therapeutic agents. These cells can also explore the pathological mechanisms contributing to neuronal degeneration.

Vial contains approximately 500,000 cells. Shipped with dry ice.

Cell Characteristics

Stability & Storage

Protocols & Documentation

Overview

Cells isolated from red marrow collected from a single adult human donor and then passaged three times to assure consistency. Vial contains approximately 500,000 cells. Shipped with dry ice.

Bone marrow-derived mesenchymal cells (BMSCs) contribute to the homeostasis of musculoskeletal tissue as well as support for the growth and differentiation of primitive hemopoietic cells.

BMSCs are extremely versatile and have been used in a host of tissue differentiation
applications including but not limited to adipogenic, chondrogenic, osteogenic and neural cell like conversions. These cells can be used for a range of tissue engineering and regenerative medicine applications.

cell type

Neural Cells, PSC-Derived, Pluripotent Stem Cells

Application

Cell Culture, Differentiation

Brand

STEMdiff

Area of Interest

Disease Modeling, Drug Discovery and Toxicity Testing, Neuroscience, Cell Therapy Development

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Product Information

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Cells
Growth type
Derivation
Doner age
Doner ethnicity
Genes expressed
Karyotype
STR
Tumorigenic
Expression markers
Additional comments
Cell Media
None
Growth Factors
Activity (primary)
Specific activity
Molecular weight
Purity
Endotoxin concentration
Conjugate
Form
Formulation
GeneID
Accession number
Amino acid sequence
Species reactivity

Documentation

Product Sheet

Certificate of Analysis

Satety Data Sheet

Protocol

Data pending from client

Data pending from client

Data pending from client

Data pending from client

Data pending from client

Data pending from client

References

Rúben Luz, Rita Cordeiro, ..., Ralph Urbatzka
Marine Drugs | 2024 Sep 10

"Abstract: A ligand (HL) was synthesized from the pyridoxal hydrochloride (vitamin B6 form) and 1-(2-Aminoethyl)piperidine in one single step. The metal complexes [Zn(L)(Bpy)]NO 3 (1), [Cu(L)(Bpy)]NO 3 (2), and [Co(L)(Bpy)]NO 3 (3) were prepared by tethering HL and 2,2'-bipyridine. The synthesized HL and metal complexes 1-3 were thoroughly characterized using spectroscopic techniques such as 1 H NMR, 13 C NMR, FTIR, EI-MS, molar conductance, and magnetic moment, in addition to CHN elemental analysis" Read More

Hend A. Hekal, Maha M. Salem, Hayam A. Abd El Salam
BMC Chemistry | 2024 Sep 18

"Abstract: Mammary gland (MCF-7;# ATCC HTB-22 ), colorectal adenocarcinoma (Caco-2; # ATCC HTB-37 ), hepatocellular carcinoma (HepG-2; # ATCC HB-8065 ), and human lung fibroblast (WI-38; # ATCC CCL-75 ).. The ATCC cell line was obtained via the Holding Company for Biological Products and .."
Read More

Yong Zhang, Shaowei Han, ..., Junfei Jin
Animal Cells and Systems | 2024 Sep 17

"Abstract: A ligand (HL) was synthesized from the pyridoxal hydrochloride (vitamin B6 form) and 1-(2-Aminoethyl)piperidine in one single step. The metal complexes [Zn(L)(Bpy)]NO 3 (1), [Cu(L)(Bpy)]NO 3 (2), and [Co(L)(Bpy)]NO 3 (3) were prepared by tethering HL and 2,2'-bipyridine. The synthesized HL and metal complexes 1-3 were thoroughly characterized using spectroscopic techniques such as 1 H NMR, 13 C NMR, FTIR, EI-MS, molar conductance, and magnetic moment, in addition to CHN elemental analysis" Read More